Tom Brown Group

Interaction of oligonucleotide-conjugates with the dipeptide transporter system in caco-2 cells

V. A. Moore, D. J. Dunnion, T. Brown, W. J. Irwin and S. Akhtar. Biochem. Pharmacol. 53 (9), 1223-1228, 1997.

Hydrogen-bonding patterns observed in the base pairs of duplex oligonucleotides

W. N. Hunter, G. A. Leonard and T. Brown. Symposium on Molecular Modeling of Nucleic Acids, at the 213th National Meeting of the American-Chemical-Society, San Francisco 77-90, 1997.

A comparative study of digoxigenin, 2,4-dinitrophenyl, and alkaline phosphatase as deoxyoligonucleotide labels in non- radioisotopic in situ hybridisation

S. J. Harper, E. Bailey, C. M. McKeen, A. S. J. Stewart, J. H. Pringle, J. Feehally and T. Brown. J. Clin. Pathol. 50 (8), 686-690, 1997.

The effect of pH on the thermally induced melting of two intra- molecular oligonucleotide triplexes: Calorimetric studies

L. Haq, B. Z. Chowdhry, T. Brown and A. N. Lane. Biophys. J. 72 (2), TH447-TH447, 1997.

Conformational properties and thermodynamics of the RNA duplex r(CGCAAAUUUGCG)2: Comparison with the DNA analogue d(CGCAAATTTGCG)2

M. R. Conte, G. L. Conn, T. Brown and A. N. Lane. Nucleic Acids Res. 25 (13), 2627-2634, 1997.

Non-Watson-Crick base associations in DNA and RNA revealed by single crystal X-ray diffraction methods: Mismatches, modified bases, and nonduplex DNA

T. Brown and W. N. Hunter. Biopolymers 44 (1), 91-103, 1997.

Comparison of the electrophoretic and hydrodynamic properties of DNA and RNA oligonucleotide duplexes

G. F. Bonifacio, T. Brown, G. L. Conn and A. N. Lane. Biophys. J. 73 (3), 1532-1538, 1997.

Solution conformation of an intramolecular DNA triplex containing a nonnucleotide linker: Comparison with the DNA duplex

J. P. Bartley, T. Brown and A. N. Lane. Biochemistry 36 (47), 14502-14511, 1997.

H-1-NMR characterization of L-tryptophan binding to TRAP, the trp RNA-binding attenuation protein of Bacillus subtilis

V. Ramesh and T. Brown. Biochem. J 315, 895-900, 1996.

Antibody-mediated detection and physical properties of oligonucleotides labelled with multiple internal and terminal 2,4-dinitrophenyl groups.

J. McClean, A. Davison, M. V. Rao and T. Brown. Biomed. Pept. Proteins Nucleic Acids 2 (1), 7-12, 1996.

Comparison of the thermodynamic stabilities and solution conformations of DNA.RNA hybrids containing purine- rich and pyrimidine-rich strands with DNA and RNA duplexes

J. I. Gyi, G. L. Conn, A. N. Lane and T. Brown. Biochemistry 35 (38), 12538-12548, 1996.

Synthesis and properties of DNA-PNA chimeric oligomers

P. J. Finn, N. J. Gibson, R. Fallon, A. Hamilton and T. Brown. Nucleic Acids Res. 24 (17), 3357-3363, 1996.

Hydration of the RNA duplex r(CGCAAAUUUGCG)2 determined by NMR

M. R. Conte, G. L. Conn, T. Brown and A. N. Lane. Nucleic Acids Res. 24 (19), 3693-3699, 1996.

Amplification of antibody production by phosphorothioate oligodeoxynucleotides

R. F. Branda, A. L. Moore, A. R. Lafayette, L. Mathews, R. Hong, G. Zon, T. Brown and J. J. McCormack. J. Lab. Clin. Med. 128 (3), 329-338, 1996.

The crystal structure analysis of d(CGCGAASSCGCG)2, a synthetic DNA dodecamer duplex containing four 4'-thio-2'-deoxythymidine nucleotides

T. J. Boggon, E. L. Hancox, K. E. McAuley-Hecht, B. A. Connolly, W. N. Hunter, T. Brown, R. T. Walker and G. A. Leonard. Nucleic Acids Res. 24 (5), 951-961, 1996.

The Structural Basis of Specific Base-Excision Repair by Uracil-DNA Glycosylase

R. Savva, K. E. McAuley-Hecht, T. Brown and L. Pearl. Nature 373 (6514), 487-493, 1995.

Self-Association of a DNA Loop Creates a Quadruplex - Crystal- Structure of d(GCATGCT) at 1.8-Angstrom Resolution

G. A. Leonard, S. Zhang, M. R. Peterson, S. J. Harrop, J. R. Helliwell, W. B. T. Cruse, B. L. Destaintot, O. Kennard, T. Brown and W. N. Hunter. Structure 3 (4), 335-340, 1995.

Do C-H...O Hydrogen-Bonds Contribute to the Stability of Nucleic-Acid Base-Pairs?

G. A. Leonard, K. E. McAuley-Hecht, T. Brown and W. N. Hunter. Acta Crystallogr. Sect. D. Biol. Crystallogr. 51, 136-139, 1995.

Cholesteryl-Conjugated Phosphorothioate Oligodeoxynucleotides Modulate Cyp2b1 Expression in-Vivo

J. Desjardins, J. Mata, T. Brown, D. Graham, G. Zon and P. Iversen. J. Drug Targeting 2 (6), 477-485, 1995.

Synthesis and Antibody-Mediated Detection of 2,4-Dinitrophenyl (DNP) Labeled Oligonucleotides

A. Davison, G. Duckworth, M. V. Rao, J. McClean, J. Grzybowski, P. Potier, T. Brown and H. Cubie. Nucleosides Nucleotides 14 (3-5), 1049-1052, 1995.