Tom Brown Group

Efficient RNA synthesis by in vitro transcription of a triazole-modified DNA template

A. H. El-Sagheer and T. Brown. Chem. Commun. 47 (44), 12057-12058, 2011.

Biocompatible artificial DNA linker that is read through by DNA polymerases and is functional in Escherichia coli

A. H. El-Sagheer, A. P. Sanzone, R. Gao, A. Tavassoli and T. Brown. Proc. Natl. Acad. Sci. U.S.A. 108 (28), 11338-11343, 2011.

New strategy for the synthesis of chemically modified RNA constructs exemplified by hairpin and hammerhead ribozymes

A. H. El-Sagheer and T. Brown. Proc. Natl. Acad. Sci. U.S.A. 107 (35), 15329-15334, 2010.

Click chemistry with DNA

A. H. El-Sagheer and T. Brown. Chem. Soc. Rev. 39 (4), 1388-1405, 2010.

High throughput measurement of duplex, triplex and quadruplex melting curves using molecular beacons and a LightCycler

R. A. J. Darby, M. Sollogoub, C. M. McKeen, L. Brown, A. Risitano, N. Brown, C. Barton, T. Brown and K. R. Fox. Nucleic Acids Res. 30 (9), e39, 2002.

Structure of an adenine-cytosine base pair in DNA and its implications for mismatch repair

W. N. Hunter, T. Brown, N. N. Anand and O. Kennard. Nature 320 (6062), 552-555, 1986.

Synthesis, Biophysical and Biological Evaluation of Splice-Switching Oligonucleotides with Multiple LNA-Phosphothiotriester Backbones

Dhara, Debashis; Hill, Alyssa; Ramesh, Abinaya; Wood, Matthew; El-Sagheer, Afaf; Brown, Tom.. Journal of the American Chemical Society 146, 29773-29781, 2024.

Synthesis and Polymerase Chain Reaction Amplification of DNA Strands Containing an Unnatural Triazole Linkage

A. H. El-Sagheer and T. Brown. J. Am. Chem. Soc. 131 (11), 3958-3964, 2009.

DNA Polymorphism as an Origin of Adenine-Thymine Tract Length-Dependent Threading Intercalation Rate

P. Nordell, F. Westerlund, A. Reymer, A. H. El-Sagheer, T. Brown, B. Norden and P. Lincoln. J. Am. Chem. Soc. 130 (44), 14651-14658, 2008.

SERS-Melting: A New Method for Discriminating Mutations in DNA Sequences

S. Mahajan, J. A. Richardson, T. Brown and P. N. Bartlett. J. Am. Chem. Soc. 130 (46), 15589-15601, 2008.

Rapid and efficient DNA strand cross-linking by click chemistry

P. Kocalka, A. H. El-Sagheer and T. Brown. ChemBioChem 9 (8), 1280-1285, 2008.

Rapid typing of STRs in the human genome by HyBeacon (R) melting

N. Gale, D. J. French, R. L. Howard, D. G. McDowell, P. G. Debenham and T. Brown. Org. Biomol. Chem. 6 (24), 4553-4559, 2008.

Interrogation of short tandem repeats using fluorescent probes and melting curve analysis: A step towards rapid DNA identity screening

D. J. French, R. L. Howard, N. Gale, T. Brown, D. G. McDowell and P. G. Debenham. Forensic Sci. Int. Genet. 2 (4), 333-339, 2008.

Addressable high-information-density DNA nanostructures

J. Tumpane, P. Sandin, R. Kumar, V. E. C. Powers, E. P. Lundberg, N. Gale, P. Baglioni, J. M. Lehn, B. Albinsson, P. Lincoln, L. M. Wilhelmsson, T. Brown and B. Norden. Chem. Phys. Lett. 440 (1), 125-129, 2007.

Template-directed oligonucleotide strand ligation, covalent intramolecular DNA circularization and catenation using click chemistry

R. Kumar, A. H. El-Sagheer, J. Tumpane, P. Lincoln, L. M. Wilhelmsson and T. Brown. J. Am. Chem. Soc. 129 (21), 6859-6864, 2007.

Four base recognition by triplex-forming oligonucleotides at physiological pH

D. A. Rusling, V. E. C. Powers, R. T. Ranasinghe, Y. Wang, S. D. Osborne, T. Brown and K. R. Fox. Nucleic Acids Res. 33 (9), 3025-3032, 2005.

Duplex Scorpion primers in SNP analysis and FRET applications

A. Solinas, L. J. Brown, C. M. McKeen, J. M. Mellor, J. T. G. Nicol, N. Thelwell and T. Brown. Nucleic Acids Res. 29 (20), 96, 2001.

Detection of PCR products using self-probing amplicons and fluorescence

D. Whitcombe, J. Theaker, S. P. Guy, T. Brown and S. Little. Nat. Biotechnol. 17 (8), 804-807, 1999.

Structure of a DNA base-excision product resembling a cisplatin inter-strand adduct

T. E. Barrett, R. Savva, T. Barlow, T. Brown, J. Jiricny and L. H. Pearl. Nat. Struct. Biol. 5 (8), 697-701, 1998.

The Structural Basis of Specific Base-Excision Repair by Uracil-DNA Glycosylase

R. Savva, K. E. McAuley-Hecht, T. Brown and L. Pearl. Nature 373 (6514), 487-493, 1995.