Tom Brown Group

Nanofabrication yields. Hybridization and click-fixation of polycyclic DNA nanoassemblies.

E. P. Lundberg, C. Plesa, L. M. Wilhelmsson, P. Lincoln, T. Brown and B. Norden. ACS Nano 5 (9), 7565-7575, 2011.

Biocompatible artificial DNA linker that is read through by DNA polymerases and is functional in Escherichia coli

A. H. El-Sagheer, A. P. Sanzone, R. Gao, A. Tavassoli and T. Brown. Proc. Natl. Acad. Sci. U.S.A. 108 (28), 11338-11343, 2011.

Discrimination against the Cytosine Analog tC by Escherichia coli DNA Polymerase IV DinB

J. M. Walsh, I. Bouamaied, T. Brown, L. M. Wilhelmsson and P. J. Beuning. J. Mol. Biol. 409 (2), 89-100, 2011.

Fast Copper-Free Click DNA Ligation by the Ring Strain Promoted Alkyne-Azide Cycloaddition Reaction

M. Shelbourne, X. Chen, T. Brown and A. H. El-Sagheer. Chem. Commun. 47, 6257-6259, 2011.

2’-Substituted 2-Amino-3-Methylpyridine Ribonucleosides in Triplex-Forming Oligonucleotides: Triplex Stability is Determined by Chemical Environment

C. Lou, Q. Xiao, R. R. Tailor, N. Ben Gaied, N. Gale, M. E. Light, K. R. Fox and T. Brown. Med. Chem. Comm. 2, 550-558, 2011.

Hydroxylation of methylated CpG dinucleotides reverses stabilisation of DNA duplexes by cytosine 5-methylation

A. Thalhammer, A. S. Hansen, A. H. El-Sagheer, T. Brown and C. J. Schofield. Chem. Commun. 47, 5325-5327, 2011.

Formation of stable DNA triplexes

K. R. Fox and T. Brown. Biochem. Soc. Trans. 39 (2), 629-634, 2011.

Ultrasensitive fluorescence-based methods for nucleic acid detection: towards amplification-free genetic analysis

R. T. Ranasinghe and T. Brown. Chem. Commun. 47, 3717-3735, 2011.

Characterization of photophysical and base-mimicking properties of a novel fluorescent adenine analogue in DNA

A. Dierckx, P. Diner, A. H. El-Sagheer, J. D. Kumar, T. Brown, M. Grotli and L. M. Wilhelmsson. Nucleic Acids Res. 39 (10), 4513-4524, 2011.

Improved synthesis of 5-hydroxymethyl-2'-deoxycytidine phosphoramidite using a 2'-deoxyuridine to 2'-deoxycytidine conversion without temporary protecting groups

A. S. Hansen, A. Thalhammer, A. H. El-Sagheer, T. Brown and C. J. Schofield. Bioorg. Med. Chem. Lett. 21 (4), 1181-1184, 2011.

Gauging the Flexibility of Fluorescent Markers for the Interpretation of Fluorescence Resonance Energy Transfer

J. J. Rindermann, Y. Akhtman, J. A. Richardson, T. Brown and P. G. Lagoudakis. J. Am. Chem. Soc. 133 (2), 279-285, 2011.

Rapid chemical ligation of oligonucleotides by the Diels–Alder reaction

A. H. El-Sagheer, V. V. Cheong and T. Brown. Org. Biomol. Chem. 9 (1), 232-235, 2011.

Six-Colour HyBeacon Probes for Multiplex Genetic Analysis

J. A. Richardson, M. Gerowska, M. Shelbourne, D. J. French and T. Brown. ChemBioChem 11 (18), 2530-2533, 2010.

CG base pair recognition within DNA triple helices by modified N-methylpyrrolo-dC nucleosides

S. R. Gerrard, M. M. Edrees, I. Bouamaied, K. R. Fox and T. Brown. Org. Biomol. Chem. 8 (22), 5087-5096, 2010.

Functionalized Nanostructures: Redox-Active Porphyrin Anchors for Supramolecular DNA Assemblies

K. Borjesson, J. Wiberg, A. H. El-Sagheer, T. Ljungdahl, J. Martensson, T. Brown, B. Norden and B. Albinsson. ACS Nano 4 (9), 5037–5046, 2010.

Analysis of Short Tandem Repeats by Using SERS Monitoring and Electrochemical Melting

D. K. Corrigan, N. Gale, T. Brown and P. N. Bartlett. Angew. Chem. Int. Ed. 49 (34), 5917-5920, 2010.

New strategy for the synthesis of chemically modified RNA constructs exemplified by hairpin and hammerhead ribozymes

A. H. El-Sagheer and T. Brown. Proc. Natl. Acad. Sci. U.S.A. 107 (35), 15329-15334, 2010.

Synthesis and properties of triplex-forming oligonucleotides containing 2'-O-(2-methoxyethyl)-5-(3-aminoprop-1-ynyl)-uridine

C. Lou, Q. Xiao, L. Brennan, M. E. Light, N. Vergara-Irigaray, E. M. Atkinson, L. M. Holden-Dye, K. R. Fox and T. Brown. Bioorg. Med. Chem. 18 (17), 6389-6397, 2010.

Peptide nucleic acid probes with charged photocleavable mass markers: Towards PNA-based MALDI-TOF MS genetic analysis

R. J. Ball, P. S. Green, N. Gale, G. J. Langley and T. Brown. Artificial DNA: PNA & XNA 1 (1), 27-35, 2010.

End-capped HyBeacon probes for the analysis of human genetic polymorphisms related to warfarin metabolism

N. Ben Gaied, J. A. Richardson, D. G. Singleton, Z. Y. Zhao, D. French and T. Brown. Org. Biomol. Chem. 8 (12), 2728-2734, 2010.