Tom Brown Group

A stretched conformation of DNA with a biological role?

N. Bosaeus, A. Reymer, T. Beke-Somfai, T. Brown, M. Takahashi, P. Wittung-Stafshede, S. Rocha and B. Nordén. Q. Rev. Biophys 50 (11), 1-11, 2017.

Modulation of Mitochondriotropic Properties of Cyanine Dyes by In Organello Copper-Free Click Reaction

I. Negwer, M. Hirsch, S. Kaloyanova, T. Brown, K. Peneva, H. Butt, K. Koynov and M. Helm. ChemBioChem 18 (18), 1814-1818, 2017.

Locked nucleic acid (LNA) enhances binding affinity of triazole-linked DNA towards RNA

P. Kumar, A. H. El-Sagheer, L. Truong and T. Brown. Chem. Commun. 53, 8910-8913, 2017.

The Sedimentation of Colloidal Nanoparticles in Solution and Its Study Using Quantitative Digital Photography

J. Midelet, A. H. El-Sagheer, T. Brown, A. G. Kanaras and M. H. V. Werts. Part. Part. Syst. Char. 2017.

Site-selective immobilization of functionalized DNA origami on nanopatterned Teflon AF

M. Shaali, J. G. Woller, P. G. Johansson, J. K. Hannestad, L. de Battice, N. Aissaoui, T. Brown, A. H. El-Sagheer, S. Kubatkin, S. Lara-Avila, B. Albinsson and A. Jesorka. J. Mater. Chem. C 5, 7637-7643, 2017.

CRISPRi is not strand-specific and redefines the transcriptional landscape

F. S. Howe, A. Russell, A. El-Sagheer, A. Nair, T. Brown and J. Mellor. eLife 6, 29878, 2017.

Instrument-free quantitative gold nanoparticle-based liquid-phase colorimetric assays for use in resource-poor environments

H. Wang, Y. Zhang, R. Li, J. Nie, A. H. El-Sagheer, T. Brown, Z. Liu and W. Xiao. Chem. Commun. 53, 8407-8410, 2017.

Towards complete sequence flexibility of nucleic acid base analogue FRET

M. S. Wranne, A. F. Füchtbauer, B. Dumat, M. Bood, A. H. El-Sagheer, T. Brown, H. Gradén, M. Grøtli and L. M. Wilhelmsson. J. Am. Chem. Soc. 139 (27), 9271-9280, 2017.

RPA activates the XPF-ERCC1 endonuclease to initiate processing of DNA interstrand crosslinks

U. B. Abdullah, J. F. McGouran, S. Brolih, D. Ptchelkine, A. H. El-Sagheer, T. Brown and P. J. McHugh. EMBO J. 36, 2047-2060, 2017.

5-Formylcytosine does not change the global structure of DNA

J. S. Hardwick, D. Ptchelkine, A. H. El-Sagheer, I. Tear, D. Singleton, S. E. V. Phillips, A. N. Lane and T. Brown. Nat. Struct. Mol. Biol. 24, 544-552, 2017.

Molecular Requirements of High-Fidelity Replication-Competent DNA Backbones for Orthogonal Chemical Ligation

A. Shivalingam, A. E. S. Tyburn, A. H. El-Sagheer and T. Brown. J. Am. Chem. Soc. 139 (4), 1575-1583, 2017.

Graphene Oxide-Upconversion Nanoparticle Based Optical Sensors for Targeted Detection of mRNA Biomarkers Present in Alzheimer’s Disease and Prostate Cancer

P. Vilela, A. H. El-Sagheer, T. M. Millar, T. Brown, O. L. Muskens and A. G. Kanaras. ACS Sensors 2 (1), 52-56, 2017.

Electrophilic RNA for Peptidyl-RNA Synthesis and Site-Specific Cross-Linking with tRNA-Binding Enzymes

M. Fonvielle, N. Sakkas, L. Iannazzo, C. Le Fournis, D. Patin, D. Mengin-Lecreulx, A. H. El-Sagheer, E. Braud, S. Cardon, T. Brown, M. Arthur and M. Etheve-Quelquejeu. Angew. Chem. Int. Ed. 55 (43), 13553-13557, 2016.

Selective killing of cells triggered by their mRNA signature in the presence of smart nanoparticles

A. Heuer-Jungemann, A. H. El-Sagheer, P. M. Lackie, T. Brown and A. G. Kanaras. Nanoscale 8, 16857-16861, 2016.

2'-Alkynylnucleotides: A Sequence- and Spin Label-Flexible Strategy for EPR Spectroscopy in DNA

M. M. Haugland, A. H. El-Sagheer, R. J. Porter, J. Pena, T. Brown, E. A. Anderson and J. E. Lovett. J. Am. Chem. Soc. 2016.

Combination probes with intercalating anchors and proximal fluorophores for DNA and RNA detection

J. Qiu, A. Wilson, A. H. El-Sagheer and T. Brown. Nucleic Acids Res. 2016.

Stabilisation of self-assembled DNA crystals by triplex-directed photo-cross-linking

H. O. Abdallah, Y. P. Ohayon, A. R. Chandrasekaran, R. Sha, K. R. Fox, T. Brown, D. A. Rusling, C. Maoe and N. C. Seeman. Chem. Commun. 2016.

An autonomous molecular assembler for programmable chemical synthesis

W. Meng, R. A. Muscat, M. L. McKee, P. J. Milnes, A. H. El-Sagheer, J. Bath, B. G. Davis, T. Brown, R. K. O'Reilly and A. J. Turberfield. Nat. Chem. 2016.

New two dimensional liquid-phase colorimetric assay based on old iodine-starch complexation for simple, low-cost, portable, naked-eye detection and quantification of analytes

J. Nie, T. Brown and Y. Zhang. Chem. Commun. 2016.

Stable End-Sealed DNA as Robust Nano-rulers for In Vivo Single-Molecule Fluorescence

A. Plochowietz, A. H. El-Sagheer, T. Brown and A. N. Kapanidis. Chem. Sci. 2016.