Dr Harvey Lou

Dr Harvey Lou

Post-doctoral researcher (2011-2012)

Harvey completed his B.Sc in Pharmacy in the School of Pharmacy, Shangdong University, China in 2002. He then studied for an M. Phil. in Medicinal Chemistry at the Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), China (2003-2006). Harvey joined the Brown group in October 2007 to start his PhD and, after completing his PhD in 2011, stayed on for a 1-year post-doc. In 2012 he joined Jesper Wengel’s group in Odense, Denmark.

4 Papers

Synthesis and properties of triplex-forming oligonucleotides containing 2'-O-(2-methoxyethyl)-5-(3-aminoprop-1-ynyl)-uridine

C. Lou, Q. Xiao, L. Brennan, M. E. Light, N. Vergara-Irigaray, E. M. Atkinson, L. M. Holden-Dye, K. R. Fox and T. Brown. Bioorg. Med. Chem. 18 (17), 6389-6397, 2010.

2’-Substituted 2-Amino-3-Methylpyridine Ribonucleosides in Triplex-Forming Oligonucleotides: Triplex Stability is Determined by Chemical Environment

C. Lou, Q. Xiao, R. R. Tailor, N. Ben Gaied, N. Gale, M. E. Light, K. R. Fox and T. Brown. Med. Chem. Comm. 2, 550-558, 2011.

2'-Aminoethoxy-2-amino-3-methylpyridine in Triplex-Forming Oligonucleotides: High Affinity, Selectivity and Resistance to Enzymatic Degradation

C. Lou, M. Shelbourne, K. R. Fox and T. Brown. Chem. Eur. J. 17 (52), 14851-14856, 2011.

Enhanced H-bonding and pi-stacking in DNA: A potent duplex-stabilizing and mismatch sensing nucleobase analogue

C. Lou, A. Dallmann, P. Marafini, R. Gao and T. Brown. Chem. Sci. 5 (10), 3836-3844, 2014.