Prof. Andrew Lane

Prof. Andrew Lane

Prof. Lane holds the James Graham Brown Chair of Structural Biology, University of Louisville, Kentucky, and is Director of the James Graham Brown Cancer Center NMR Facility.

28 Papers

NMR Determination of the Solution Conformation and Dynamics of the A.G Mismatch in the d(CGCAAATTGGCG)2 Dodecamer

A. N. Lane, T. C. Jenkins, D. J. S. Brown and T. Brown. Biochem. J 279, 269-281, 1991.

Interaction of Berenil with the Eco.RI Dodecamer d(CGCGAATTCGCG)2 in Solution Studied by NMR

A. N. Lane, T. C. Jenkins, T. Brown and S. Neidle. Biochemistry 30 (5), 1372-1385, 1991.

Conformational Properties of the G.G Mismatch in d(CGCGAATTGGCG)2 Determined by NMR

K. L. B. Borden, T. C. Jenkins, J. V. Skelly, T. Brown and A. N. Lane. Biochemistry 31 (23), 5411-5422, 1992.

Very Stable Mismatch Duplexes - Structural and Thermodynamic Studies on Tandem G.A Mismatches in DNA

S. Ebel, A. N. Lane and T. Brown. Biochemistry 31 (48), 12083-12086, 1992.

Solution Conformation of a Deoxyoligonucleotide Containing Tandem G.A Mismatched Base-Pairs and 3'-Overhanging Ends in d(GTGAACTT)2

A. N. Lane, S. R. Martin, S. Ebel and T. Brown. Biochemistry 31 (48), 12087-12095, 1992.

NMR Assignments and Solution Conformation of the DNA.RNA Hybrid Duplex d(GTGAACTT).r(AAGUUCAC)

A. N. Lane, S. Ebel and T. Brown. Eur. J. Biochem. 215 (2), 297-306, 1993.

Thermodynamic Stability and Solution Conformation of Tandem G.A Mismatches in RNA and RNA.DNA Hybrid Duplexes

S. Ebel, T. Brown and A. N. Lane. Eur. J. Biochem. 220 (3), 703-715, 1994.

Properties of Multiple G.A Mismatches in Stable Oligonucleotide Duplexes

A. N. Lane, S. Ebel and T. Brown. Eur. J. Biochem. 220 (3), 717-727, 1994.

Hydration of the RNA duplex r(CGCAAAUUUGCG)2 determined by NMR

M. R. Conte, G. L. Conn, T. Brown and A. N. Lane. Nucleic Acids Res. 24 (19), 3693-3699, 1996.

Comparison of the thermodynamic stabilities and solution conformations of DNA.RNA hybrids containing purine- rich and pyrimidine-rich strands with DNA and RNA duplexes

J. I. Gyi, G. L. Conn, A. N. Lane and T. Brown. Biochemistry 35 (38), 12538-12548, 1996.

Solution conformation of an intramolecular DNA triplex containing a nonnucleotide linker: Comparison with the DNA duplex

J. P. Bartley, T. Brown and A. N. Lane. Biochemistry 36 (47), 14502-14511, 1997.

Comparison of the electrophoretic and hydrodynamic properties of DNA and RNA oligonucleotide duplexes

G. F. Bonifacio, T. Brown, G. L. Conn and A. N. Lane. Biophys. J. 73 (3), 1532-1538, 1997.

Conformational properties and thermodynamics of the RNA duplex r(CGCAAAUUUGCG)2: Comparison with the DNA analogue d(CGCAAATTTGCG)2

M. R. Conte, G. L. Conn, T. Brown and A. N. Lane. Nucleic Acids Res. 25 (13), 2627-2634, 1997.

The effect of pH on the thermally induced melting of two intra- molecular oligonucleotide triplexes: Calorimetric studies

L. Haq, B. Z. Chowdhry, T. Brown and A. N. Lane. Biophys. J. 72 (2), TH447-TH447, 1997.

Coralyne has a preference for intercalation between TA.T triplets in intramolecular DNA triple helices

A. A. Moraru-Allen, S. Cassidy, J. L. A. Alvarez, K. R. Fox, T. Brown and A. N. Lane. Nucleic Acids Res. 25 (10), 1890-1896, 1997.

The dependence of DNase I activity on the conformation of oligodeoxynucleotides

D. H. Sutton, G. L. Conn, T. Brown and A. N. Lane. Biochem. J 321, 481-486, 1997.

Comparison of the solution structures of intramolecular DNA triple helices containing adjacent and non-adjacent CG.C+ triplets

J. L. Asensio, T. Brown and A. N. Lane. Nucleic Acids Res. 26 (16), 3677-3686, 1998.

The contribution of cytosine protonation to the stability of parallel DNA triple helices

J. L. Asensio, A. N. Lane, J. Dhesi, S. Bergqvist and T. Brown. J. Mol. Biol. 275 (5), 811-822, 1998.

Solution structures of DNA.RNA hybrids with purine- rich and pyrimidine-rich strands: Comparison with the homologous DNA and RNA duplexes

J. I. Gyi, A. N. Lane, G. L. Conn and T. Brown. Biochemistry 37 (1), 73-80, 1998.

The orientation and dynamics of the C2'-OH and hydration of RNA and DNA-RNA hybrids

J. I. Gyi, A. N. Lane, G. L. Conn and T. Brown. Nucleic Acids Res. 26 (13), 3104-3110, 1998.

Solution conformation of a parallel DNA triple helix with 5' and 3' triplex-duplex junctions

J. L. Asensio, T. Brown and A. N. Lane. Structure 7 (1), 1-11, 1999.

Conformational and thermodynamic properties of parallel intramolecular triple helices containing a DNA, RNA, or 2'- OMeDNA third strand

J. L. Asensio, R. Carr, T. Brown and A. N. Lane. J. Am. Chem. Soc. 121 (48), 11063-11070, 1999.

The solution structure of a DNA.RNA duplex containing 5-propynyl U and C; comparison with 5-Me modifications

J. I. Gyi, D. Q. Gao, G. L. Conn, J. O. Trent, T. Brown and A. N. Lane. Nucleic Acids Res. 31 (10), 2683-2693, 2003.

Determining the origin of the stabilization of DNA by 5- aminopropynylation of pyrimidines

J. Booth, T. Brown, S. J. Vadhia, O. Lack, W. J. Cummins, J. O. Trent and A. N. Lane. Biochemistry 44 (12), 4710-4719, 2005.

A very stable cyclic DNA miniduplex with just two base pairs

A. H. El-Sagheer, R. Kumar, S. Findlow, J. M. Werner, A. N. Lane and T. Brown. ChemBioChem 9 (1), 50-52, 2008.

Structural analysis of the DNA target site and its interaction with Mbp1

A. V. Chernatynskaya, L. Deleeuw, J. O. Trent, T. Brown and A. N. Lane. Org. Biomol. Chem. 7 (23), 4981-4991, 2009.

5-Formylcytosine does not change the global structure of DNA

J. S. Hardwick, D. Ptchelkine, A. H. El-Sagheer, I. Tear, D. Singleton, S. E. V. Phillips, A. N. Lane and T. Brown. Nat. Struct. Mol. Biol. 24, 544-552, 2017.

Epigenetic Modifications of Cytosine: Biophysical Properties, Regulation, and Function in Mammalian DNA

J. S. Hardwick, A. N. Lane and T. Brown. BioEssays 40 (3), 2018.